Een studie, een stage, een baan!

Vorig jaar oktober was de bekroning van, laat ik zeggen, niet de zes zwaarste jaren uit mijn leven. Zonder blikken of blozen kan ik zeggen, dat Bestuurskunde een studie is waar je veel dingen naast kunt doen. Hieronder zal ik terugblikken op de afgelopen zes mooie en leerzame studiejaren. Bovendien zal ik mijn eerste baan als afgestudeerd bestuurskundige beschrijven. Sinds mei vorig jaar ben ik namelijk werkzaam als persoonlijk medewerker van VVD Tweede-Kamerlid Henk Kamp

Robust and Efficient Uncertainty Quantification and Validation of RFIC Isolation

Modern communication and identification products impose demanding constraints on reliability of components. Due to this statistical constraints more and more enter optimization formulations of electronic products. Yield constraints often require efficient sampling techniques to obtain uncertainty quantification also at the tails of the distributions. These sampling techniques should outperform standard Monte Carlo techniques, since these latter ones are normally not efficient enough to deal with tail probabilities. One such a technique, Importance Sampling, has successfully been applied to optimize Static Random Access Memories (SRAMs) while guaranteeing very small failure probabilities, even going beyond 6-sigma variations of parameters involved. Apart from this, emerging uncertainty quantifications techniques offer expansions of the solution that serve as a response surface facility when doing statistics and optimization. To efficiently derive the coefficients in the expansions one either has to solve a large number of problems or a huge combined problem. Here parameterized Model Order Reduction (MOR) techniques can be used to reduce the work load. To also reduce the amount of parameters we identify those that only affect the variance in a minor way. These parameters can simply be set to a fixed value. The remaining parameters can be viewed as dominant. Preservation of the variation also allows to make statements about the approximation accuracy obtained by the parameter-reduced problem. This is illustrated on an RLC circuit. Additionally, the MOR technique used should not affect the variance significantly. Finally we consider a methodology for reliable RFIC isolation using floor-plan modeling and isolation grounding. Simulations show good comparison with measurements

Simulations of inner magnetosphere dynamics with an expanded RAM-SCB model and comparisons with Van Allen Probes observations

Abstract Simulations from our newly expanded ring current-atmosphere interactions model with self-consistent magnetic field (RAM-SCB), now valid out to 9 R E, are compared for the first time with Van Allen Probes observations. The expanded model reproduces the storm time ring current buildup due to the increased convection and inflow of plasma from the magnetotail. It matches Magnetic Electron Ion Spectrometer (MagEIS) observations of the trapped high-energy (\u3e50 keV) ion flux; however, it underestimates the low-energy (\u3c10 keV) Helium, Oxygen, Proton, and Electron (HOPE) observations. The dispersed injections of ring current ions observed with the Energetic particle, Composition, and Thermal plasma (ECT) suite at high (\u3e20 keV) energy are better reproduced using a high-resolution convection model. In agreement with Electric and Magnetic Field Instrument Suite and Integrated Science (EMFISIS) observations, RAM-SCB indicates that the large-scale magnetic field is depressed as close as ∼4.5 RE during even a moderate storm. Regions of electromagnetic ion cyclotron instability are predicted on the duskside from ∼6 to ∼9 RE, indicating that previous studies confined to geosynchronous orbit may have underestimated their scattering effect on the energetic particles. Key Points Expanded RAM-SCB model reproduces well high-energy (\u3e50 keV) MagEIS observations The magnetic field is depressed as close as ∼4.5 RE during even a moderate storm EMIC wave growth extends on duskside from ∼6 to ∼9 RE during storm main phase

Six Years Follow-up of the Levels of TNF-α and IL-6 in Patients with Complex Regional Pain Syndrome Type 1

In an earlier study, levels of the proinflammatory cytokines TNF-α and IL-6 are higher in blisters fluid from the complex regional pain syndrome type 1 (CRPS1) side obtained at 6 and 30 months (median) after the initial event. The aim of this follow-up study is to determine the involvement of these cytokines in long lasting CRPS1. Twelve CRPS1 patients, with median disease duration of 72 months, participated. The levels of TNF-α and IL-6 were measured in blister fluid; disease activity was reevaluated by measuring pain and differences in temperature, volume, and mobility between both extremities. Differences in levels of IL-6 and TNF-α and mobility between both sides were significantly decreased. Pain and differences in temperature and volume were not significantly altered. No correlation was found between the cytokines and the disease characteristics. These results indicate that IL-6 and TNF-α are only partially responsible for the signs and symptoms of CRPS1

HNF4alpha Dysfunction as a Molecular Rational for Cyclosporine Induced Hypertension

Induction of tolerance against grafted organs is achieved by the immunosuppressive agent cyclosporine, a prominent member of the calcineurin inhibitors. Unfortunately, its lifetime use is associated with hypertension and nephrotoxicity. Several mechanism for cyclosporine induced hypertension have been proposed, i.e. activation of the sympathetic nervous system, endothelin-mediated systemic vasoconstriction, impaired vasodilatation secondary to reduction in prostaglandin and nitric oxide, altered cytosolic calcium translocation, and activation of the renin-angiotensin system (RAS). In this regard the molecular basis for undue RAS activation and an increased signaling of the vasoactive oligopeptide angiotensin II (AngII) remain elusive. Notably, angiotensinogen (AGT) is the precursor of AngII and transcriptional regulation of AGT is controlled by the hepatic nuclear factor HNF4alpha. To better understand the molecular events associated with cyclosporine induced hypertension, we investigated the effect of cyclosporine on HNF4alpha expression and activity and searched for novel HNF4alpha target genes among members of the RAS cascade. Using bioinformatic algorithm and EMSA bandshift assays we identified angiotensin II receptor type 1 (AGTR1), angiotensin I converting enzyme (ACE), and angiotensin I converting enzyme 2 (ACE2) as genes targeted by HNF4alpha. Notably, cyclosporine represses HNF4alpha gene and protein expression and its DNA-binding activity at consensus sequences to AGT, AGTR1, ACE, and ACE2. Consequently, the gene expression of AGT, AGTR1, and ACE2 was significantly reduced as evidenced by quantitative real-time RT-PCR. While RAS is composed of a sophisticated interplay between multiple factors we propose a decrease of ACE2 to enforce AngII signaling via AGTR1 to ultimately result in vasoconstriction and hypertension. Taken collectively we demonstrate cyclosporine to repress HNF4alpha activity through calcineurin inhibitor mediated inhibition of nuclear factor of activation of T-cells (NFAT) which in turn represses HNF4alpha that leads to a disturbed balance of RAS

Update on the Worsening Particle Radiation Environment Observed by CRaTER and Implications for Future Human Deep‐Space Exploration

Over the last decade, the solar wind has exhibited low densities and magnetic field strengths, representing anomalous states that have never been observed during the space age. As discussed by Schwadron, Blake, et al. (2014, https://doi.org/10.1002/2014SW001084), the cycle 23–24 solar activity led to the longest solar minimum in more than 80 years and continued into the “mini” solar maximum of cycle 24. During this weak activity, we observed galactic cosmic ray fluxes that exceeded theERobserved small solar energetic particle events. Here we provide an update to the Schwadron, Blake, et al. (2014, https://doi.org/10.1002/2014SW001084) observations from the Cosmic Ray Telescope for the Effects of Radiation (CRaTER) on the Lunar Reconnaissance Orbiter. The Schwadron, Blake, et al. (2014, https://doi.org/10.1002/2014SW001084) study examined the evolution of the interplanetary magnetic field and utilized a previously published study by Goelzer et al. (2013, https://doi.org/10.1002/2013JA019404) projecting out the interplanetary magnetic field strength based on the evolution of sunspots as a proxy for the rate that the Sun releases coronal mass ejections. This led to a projection of dose rates from galactic cosmic rays on the lunar surface, which suggested a ∼20% increase of dose rates from one solar minimum to the next and indicated that the radiation environment in space may be a worsening factor important for consideration in future planning of human space exploration. We compare the predictions of Schwadron, Blake, et al. (2014, https://doi.org/10.1002/2014SW001084) with the actual dose rates observed by CRaTER in the last 4 years. The observed dose rates exceed the predictions by ∼10%, showing that the radiation environment is worsening more rapidly than previously estimated. Much of this increase is attributable to relatively low‐energy ions, which can be effectively shielded. Despite the continued paucity of solar activity, one of the hardest solar events in almost a decade occurred in September 2017 after more than a year of all‐clear periods. These particle radiation conditions present important issues that must be carefully studied and accounted for in the planning and design of future missions (to the Moon, Mars, asteroids, and beyond).Plain Language SummaryWe examine the evolution of fluxes from galactic cosmic rays and recent solar energetic particle events to evaluate the recent evolution of radiation hazards in space and their implications for human and robotic exploration.Key PointsGCR radiation doses are rising faster than predicted previouslySEP radiation events are large despite low solar activityRadiation environment is a significant factor for mission planningPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143683/1/swe20567_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/143683/2/swe20567.pd

Thermography imaging during static and controlled thermoregulation in complex regional pain syndrome type 1: diagnostic value and involvement of the central sympathetic system

BACKGROUND: Complex Regional Pain Syndrome type 1 (CRPS1) is a clinical diagnosis based on criteria describing symptoms of the disease. The main aim of the present study was to compare the sensitivity and specificity of calculation methods used to assess thermographic images (infrared imaging) obtained during temperature provocation. The secondary objective was to obtain information about the involvement of the sympathetic system in CRPS1. METHODS: We studied 12 patients in whom CRPS1 was diagnosed according to the criteria of Bruehl. High and low whole body cooling and warming induced and reduced sympathetic vasoconstrictor activity. The degree of vasoconstrictor activity in both hands was monitored using a videothermograph. The sensitivity and specificity of the calculation methods used to assess the thermographic images were calculated. RESULTS: The temperature difference between the hands in the CRPS patients increases significantly when the sympathetic system is provoked. At both the maximum and minimum vasoconstriction no significant differences were found in fingertip temperatures between both hands. CONCLUSION: The majority of CRPS1 patients do not show maximal obtainable temperature differences between the involved and contralateral extremity at room temperature (static measurement). During cold and warm temperature challenges this temperature difference increases significantly. As a result a higher sensitivity and specificity could be achieved in the diagnosis of CRPS1. These findings suggest that the sympathetic efferent system is involved in CRPS1